Predictive factors for ovarian recovery include younger age at first chemotherapy administration and absence of concomitant radiotherapy (91)
Ovarian or egg cryopreservation and transplantation of the thawed tissue are not yet clinically established; however there is no contraindication for cryopreservation combined with GnRH agonist administration (101).
Some studies have reported the spontaneous return of ovarian function after several years in women with chemotherapy- or radiotherapy-induced ovarian failure (106, 107). The exact mechanism is unknown; however, it is theoretically possible that the constant stimulation of ovaries by postmenopausal levels of gonadotropins ent. Successful pregnancies have been reported among women who […]